Climate change is posing several challenges to the world population. Different approaches have been proposed to evaluate climate change impacts and to plan adaptation strategies, but their integration is rare. In this PhD, approaches based on indicators, such as the drought risk assessment, and agro-hydrological modelling, such as the application of SWAT+, are combined to evaluate future climate risk. The general objective is to assess the expected impacts of climate change on crop production and hydrology and to evaluate the most promising agronomic adaptation strategies, integrating drought risk assessment, climate, and agro-hydrological models, towards better water management.